The collision happened at a bend near Cushinstown church and it is under the casualties were trapped in their auto by the crash.
More details about the family who were killed in a road crash in Wexford last night have been revealed.
The four people - a couple in their 70s and their two sons, both in their forties - had come to Ireland from the U.S. for a family funeral.
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They were all the occupants of the auto, and were pronounced dead at the scene.
It is understood one woman and three men were traveling in the same auto and were all members of the same family.
The crash happened at approximately 6.30pm on the N25 on the New Ross to Ballinaboule road at Begern.
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The vehicle and lorry were both travelling eastwards towards Wexford.
The driver and passenger in the lorry were uninjured in the collision.
The road is now closed and diversions are in place as gardai examine the scene.
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The road is closed to facilitate a Forensic Collision examination and will remain closed until at least lunchtime tomorrow.