Wednesday's raid in the northern suburb Saxonworld comes as the country waits to see if President Jacob Zuma would resign after being asked to do so by the ruling African National Congress (ANC) party.
This after the ANC confirmed on Tuesday that its national executive committee (NEC), the governing party's highest decision-making structure between national conferences, resolved to recall Zuma from office following a marathon meeting on Monday of the top structure at St George Hotel in Irene, near Pretoria.
Cape Town - The noose tightened on President Jacob Zuma as the police went after key allies while leaders of the ruling African National Congress vowed to force him from office.
Zuma is already facing a no-confidence motion in parliament set for Feb 22 and brought by the opposition Economic Freedom Fighters.
Mr Ramaphosa is expected to become South Africa's new president.
On Friday his wife Tobeka Madiba-Zuma posted comments on Instagram suggesting the president, who has challenged and defied attempts by the ANC and courts to remove him, was prepared to fight and believed he was the victim of a Western conspiracy.
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Mr Zuma was replaced as the party's leader in December by his deputy, Cyril Ramaphosa, but has so far resisted calls to resign.
Magashule said the decision to recall Zuma was taken after exhaustive discussions.
Magashule said the party did not give Zuma a deadline to tender his resignation, but said they expected a quick turnaround.
Zuma's ability to survive the scandals in the past earned him the nickname "Teflon President".
On Tuesday, Cosatu, which is in an alliance with the ANC implored Zuma not to hold the country "hostage".
Zuma, 75, has denied any wrongdoing.
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Ramaphosa was due to take over as president after elections in 2019, but he and his supporters were determined to force Zuma swiftly from power, arguing that the party needed time to rebuild its declining support before then.
Besides his controversial relationship with the Guptas, who were born in India but moved to South Africa in the early 1990s, Zuma has 783 counts of corruption outstanding against him relating to a $2.5 billion state arms deal in the late 1990s.
"I don't know what will happen, but let's leave it to President Jacob Zuma", said secretary general Ace Magashule.
The impasse over the presidency has highlighted the disarray within a party that previously was the main movement against white minority rule and has led South Africa since the end of apartheid in 1994.
"This is because, among others, he faces the possibility of prosecution for alleged criminal offences and is directly associated with negative developments such as the alleged corruption of various state bodies ie state-owned enterprises, the National Prosecuting Authority, state capture and serious economic mismanagement", the foundation said in a statement.
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