Messi came on in the 60th minute for Coutinho and by the 64th, Barca were ahead.
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Among the other regular starters who didn't play on Tuesday were Andres Iniesta, Sergio Busquets, Gerard Pique, Samuel Umtiti and Luis Suarez.
Celta's Iago Aspas celebrates after scoring their second in the 2-2 draw against Barcelona at the Balaidos Stadium.
And Valverde believes such a lengthy run without defeat - which includes 33 games of this season and the final seven fixtures of 2016-17 - means they should be pleased with themselves.
The Barca starting 11 failed to contain one single player emerging from the Barca youth system, but the Catalans took the lead after 36 minutes when Ousmane Dembele scored a left foot shot from a pass by Paco Alcacer.
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But Celta took control after Roberto was sent off in the 71st with a straight red card for pulling Aspas from behind to prevent a one-on-one situation for the hosts. Celta stayed ninth in the standings with the result.
Sevilla also play on Tuesday and travel to Deportivo la Coruna, whose survival chances got a boost with a 3-2 win in Bilbao on Saturday.
The Catalan giants will be in action again this weekend, when they face Sevilla in the Copa del Rey final.
Spurs aim to bounce back in Game 2 vs. Warriors
Aldridge finished the night with a double-double and stayed out of foul trouble to give the short-handed Spurs a constant threat. The Warriors are still without their two-time MVP , but they were humming along on both ends in their 113-92 victory.