Iranian officials have not directly responded to the attack, but the supreme leader, Ayatollah Ali Khamenei, indirectly addressed the strikes on Iranians as well as the U.S. role in the region. "They know that if they get into a military conflict with Iran, they will be struck multiple times over".
The U.S., Khamenei asserted, was intentionally sowing strife between Muslim countries, especially by inciting Saudi Arabia against Shia Iran.
He also said that Iran disturbs the security of the region through arming the Houthi rebels in Yemen.
He said Washington is in no position to talk about Iran's defence capabilities.
"Pompeo's remarks about Iran are baseless and repetitive ..."
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The Hezbollah-affiliated news outlet Al-Akhbar said that Assad made the remarks Monday during a meeting with Iranian military officials in Damascus.
"Today, US Treasury Department is the operations room of war against Iran so we have to boost our economy", he said according to a report from the Almana website. It is the U.S. that "needs to leave, not the Islamic Republic", the Ayatollah went on to say, adding that western Asia is the Iranians' home, while the USA is "an outsider with mischievous aims, seeking to instigate sedition" in the region.
"The Americans do not want to bear the cost of confronting Islamic Republic", he said, adding that, instead, Washington wants "Muslims to fight Muslims".
Iran's supreme leader then warned the regional powers from giving in to the United States provocations, adding that, if they face Iran, they will "suffer a decisive defeat".
US President Donald Trump has given the European signatories a May 12 deadline to "fix the bad flaws" of the 2015 nuclear deal, or he will refuse to extend US sanctions relief on Iran.
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Under Iran's settlement with the United States, France, Germany, Britain, Russia and China, Tehran agreed to curb its nuclear program to satisfy the powers that it could not be put to developing atomic bombs.
Tensions between Shiite Iran and Sunni Saudi Arabia have been rising and both are backing opposing sides in the Yemeni civil war.
"Wherever U.S. entered, it created instability, brought misery to people; that's why U.S.'s feet must be cut off from West Asia, U.S. must exit this region", Khamenei tweeted.
Khamenei also claimed the USA wants to put the financial burden of confronting Iran on the shoulders of other Mideast countries, but warned "they will be hit and defeated if they confront Iran".
In January, Trump kept the deal alive by waiving sanctions against Iran as required by the pact every six months.
Pompeo says Israelis have 'right to defend' Gaza border
During the next four days, various Arab and global delegations are expected to participate, as well as various Palestinian groups. He said the two-state solution, one for Israelis and one for Palestinians, offers the only practical path to peace.