Breast Cancer study days some patients may not need chemo


"The impact is tremendous", said the study leader, Dr. Joseph Sparano of Montefiore Medical Center in NY.

"It does tend to cause significant side effects such as fatigue and hair loss issues that really do trouble women", said Moore.

At MedShadow, she reports on new findings and research on the side effects of prescription drugs.

The study was funded by the National Cancer Institute, some foundations and proceeds from the USA breast cancer postage stamp.

The National Cancer Institute sponsored the study, along with several foundations.

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After undergoing surgery and radiation, the women randomly received either chemotherapy plus endocrine therapy or endocrine therapy alone. When chemo is used now, it's sometimes for shorter periods or lower doses than it once was.

To conduct the study, women in the intermediate groups were either prescribed chemotherapy or given treatment absent of the use of chemotherapy. But it is only for early stage breast cancers that can still be treated with hormone therapy, have not spread to the lymph nodes, and do not have the HER2 mutation. Doctors know that most don't need it, but evidence is thin on who can forgo it.

Approximately 17 percent of girls needed high-risk scores and have been counseled to have chemo.

In the U.S., those who score low on the test - 0-10 - are already told to skip chemotherapy after their tumours are removed and they receive hormone therapy.

A new study published Sunday in the New England Journal of Medicine may drastically change how medical professionals approach treating women diagnosed with breast cancer.

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Around half of women taking aromatase inhibitors, a common drug for postmenopausal women with hormone receptor positive breast cancer, experience joint pain.

After nine Decades, 94 percent of both teams were still living, and About 84 percent were living with no signs of cancer, therefore adding chemo made no real difference.

Findings of the past have indicated that women who met these criteria and scored below ten on the index test could safely skip chemotherapy without raising their rate of recurrence, however, those above 25 would nearly always be advised to use chemotherapy as a necessary treatment to lower risk of recurrence.

- Local breast cancer doctors are excited about the results of a trial involving 10,000 women.

"We're getting to be able to personalize treatment now".

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Although the new findings are extremely promising for women who have early-stage breast cancer, the conclusions may not apply to those who have larger tumors or those battling cancer that has spread throughout the body. Oncotype DX costs around $4,000, which Medicare and many insurers cover.