Germany midfielder Emre Can will leave Liverpool when his contract expires this summer.
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Can was brought to Liverpool by Brendan Rodgers in a £10m deal from Bayer Leverkusen in 2014.
Jurgen Klopp had been keen to retain the services of the 24-year-old but the versatile midfielder failed to agree terms and is reported to have already agreed a four-year contract with Italian champions Juventus.
The defender was a mainstay of the team that challenged for the Premier League title in 2013-14, making 23 appearances as the Reds ultimately finished second, and became a senior England global.
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The 25-year-old played regularly for the club as they challenged for the Premier League title in the 2013/14 but had not featured for the senior side since the Carabao Cup defeat to Leicester City last September.
Flanagan has one England cap after playing in a friendly against Ecuador in 2014.
The Reds, meanwhile, have effectively moved to replace Can already with the £40m acquisition of Brazilian global Fabinho from Monaco.
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The other notable name on to be released by Liverpool is defender Jon Flanagan.