For many people, the challenge could be finding a safe refuge: If Florence slows to a crawl just off the coast, it could bring torrential rains to the Appalachian mountains and as far away as West Virginia, causing flash floods, mudslides and other unsafe conditions.
"Florence is quickly becoming a powerful hurricane", hurricane specialist Eric Blake wrote.
North Carolina has ordered the evacuation of more than 50,000 people.
Though the NHC can't pinpoint with certainty the exact location and magnitude of the impacts, they said, "interests at the coast and inland from SC into the mid-Atlantic region should closely monitor the progress of Florence, ensure they have their hurricane plan in place, and follow any advice given by local officials".
Florence is now projecting hurricane-force winds (74 mph and higher) up to 30 miles from its center.
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As of 5 a.m. EDT, Florence was centered about 625 miles (1,005 kilometers) southeast of Bermuda, moving west at 9 mph (15 kph).
"The bottom line is that there is high confidence that Florence will be a large and extremely risky hurricane, regardless of its exact intensity", the NHC said.
A westward motion with a slight increase in forward speed is expected through the end of the week.
NASA astronaut and current International Space Station resident Ricky Arnold was able to capture the sheer breadth of Hurricane Florence, while showcasing Isaac and an outer band of Helene in new photos posted on Twitter Monday.
From the Carolinas to Virgina residents are doing what they can to prepare. The rapidly growing hurricane-currently circling Bermuda-is expected to make contact with the East Coast early Thursday morning, predicted Wes Hohenstein, chief meteorologist at CBS 17. Forecasters say that because of the size the storm is expected to attain, it will wreak havoc regardless of how strong its winds are.
There are three hurricanes in the Atlantic Ocean. Georgia, West Virginia, Maryland, the District of Columbia, Delaware, New Jersey, southern Pennsylvania, and eastern Tennessee, Kentucky, and OH could also see strong winds.
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Unsafe storms are also threatening parts of the U.S.in the Pacific Ocean.
Experts have forecast the upgraded tropical storm will gather force - going from a category 1 hurricane to a category 3 on Monday morning.
In 2015, heavy flooding in Columbia made the logistics of hosting a game impossible, so the game was moved to LSU.
There have been six tropical storms in the Atlantic basin this year.
"I don't think many of us have ever been through a Category 4". Hurricanes Helene and Isaac are not expected to hit the USA mainland.
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